For cystic fibrosis.
Brand Name(s): ORKAMBI
Generic Name: Ivacaftor/Lumacaftor
Instructions
Keep the medicine in its original container.
Take with a high fat food.
Peel back foil, carefully remove tablet using dry hands. Do not push the tablet through the foil.
This medicine will work best if you take it at about the same time every day.
Store at room temperature away from heat, light, and moisture. Do not keep in the bathroom.
Avoid grapefruit and grapefruit juice while on this medicine.
It is important that you keep taking each dose of this medicine on time even if you are feeling well.
If you forget to take a dose on time, take it as soon as you remember. If it is less than 6 hours to the next dose, do not take the missed dose. Return to your normal dosing schedule. Do not take 2 doses of this medicine at one time.
Drug interactions can change how medicines work or increase risk for side effects. Tell your health care providers about all medicines taken. Include prescription and over-the-counter medicines, vitamins, and herbal medicines. Speak with your doctor or pharmacist before starting or stopping any medicine.
Tell your doctor if symptoms do not get better or if they get worse.
The foods you eat can change how well this medicine works. Tell your doctor about the types of food you normally eat. Ask your doctor for a list of foods that can affect this medicine. Do not significantly change the foods you normally eat while on this medicine.
This medicine may decrease the effectiveness of some birth controls which use hormones (such as birth control pills and patches). Use an extra form of birth control, such as condoms, while on this medicine.
Keep all appointments for medical exams and tests while on this medicine.
Do not take the medicine more than twice during 24 hours.
Cautions
Tell your doctor and pharmacist if you ever had an allergic reaction to a medicine.
Some patients taking this medicine have experienced serious side effects. Please speak with your doctor to understand the risks and benefits associated with this medicine.
This medicine has been associated with a rare but serious skin rash. If you notice any red, peeling or blistered skin, contact your doctor immediately.
This medicine is associated with a rare, but serious problem of the liver. Speak to your doctor about the early signs of liver problems and the benefits and risks of using this medicine.
Do not use the medication any more than instructed.
If possible, avoid using with marijuana or other medicines that can cause dizziness or drowsiness. These include allergy/cold products, muscle relaxers, sleep aids, and pain relievers.
Your ability to stay alert or to react quickly may be impaired by this medicine. Do not drive or operate machinery until you know how this medicine will affect you.
If you drink alcohol regularly, please speak with your doctor.
This medicine passes into breast milk. Ask your doctor before breastfeeding.
During pregnancy, this medicine should be used only when clearly needed. Talk to your doctor about the risks and benefits.
Do not take St. John's wort while on this medicine.
Call your doctor right away if you notice slow or shallow breathing.
Do not share this medicine with anyone who has not been prescribed this medicine.
Always refill this medicine before it runs out.
Side Effects
The following is a list of some common side effects from this medicine. Please speak with your doctor about what you should do if you experience these or other side effects.
- bloating
- diarrhea
- dizziness
- headaches
- nausea
Call your doctor or get medical help right away if you notice any of these more serious side effects:
- chest pain
- severe, watery or bloody diarrhea
- high blood pressure
- signs of liver damage (such as yellowing of eye or skin, dark urine, or unusual tiredness)
- red, burning, or itchy skin
- shortness of breath
- blurring or changes of vision
- severe or persistent vomiting
- worsening breathing symptoms
A few people may have an allergic reaction to this medicine. Symptoms can include difficulty breathing, skin rash, itching, swelling, or severe dizziness. If you notice any of these symptoms, seek medical help quickly.
Please speak with your doctor, nurse, or pharmacist if you have any questions about this medicine.
IMPORTANT NOTE: This document tells you briefly how to take your medicine, but it does not tell you all there is to know about it. Your doctor or pharmacist may give you other documents about your medicine. Please talk to them if you have any questions. Always follow their advice.
There is a more complete description of this medicine available in English. Scan this code on your smartphone or tablet or use the web address below. You can also ask your pharmacist for a printout. If you have any questions, please ask your pharmacist.
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More information about LUMACAFTOR/IVACAFTOR - ORAL
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Selected from data included with permission and copyright by First DataBank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.
Conditions of Use: The information in this database is intended to supplement, not substitute for the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. The display and use of this drug information is subject to express Terms of Use.
